abstract：:Deficient prefrontal cortex (PFC) GABA function is hypothesized to play a role in schizophrenia and other psychiatric disorders. In rodents, PFC GABAA receptor antagonism produces cognitive and behavioral changes relevant to these disorders, including impaired spatial memory assessed with the traditional working/refer...

journal_title：Brain structure & function

authors： Auger ML,Meccia J,Galea LAM,Floresco SB

更新日期：2019-01-01 00:00:00

abstract：:Diffusion tensor histology holds great promise for quantitative characterization of structural connectivity in mouse models of neurological and psychiatric conditions. There has been extensive study in both the clinical and preclinical domains on the complex tradeoffs between the spatial resolution, the number of samp...

journal_title：Brain structure & function

authors： Wang N,Anderson RJ,Badea A,Cofer G,Dibb R,Qi Y,Johnson GA

更新日期：2018-12-01 00:00:00

abstract：:Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to the poorly studied medullary paratrigeminal nucleus. In the present study, we used neuroanatomical tracing, pharmacology and physiology in guinea pig to investigate the paratrigeminal neural circuits mediating jugular ganglia-e...

journal_title：Brain structure & function

authors： Driessen AK,Farrell MJ,Dutschmann M,Stanic D,McGovern AE,Mazzone SB

更新日期：2018-12-01 00:00:00

abstract：:Anterior cingulate cortex (ACC) input to the claustrum is required for top-down cognitive control of action. By virtue of its widespread cortical connectivity, the claustrum is anatomically situated to process and broadcast top-down signals from ACC to downstream cortices. To gain a deeper understanding of claustrum p...

journal_title：Brain structure & function

authors： White MG,Mathur BN

更新日期：2018-12-01 00:00:00

abstract：:Rho-associated protein kinases (ROCK) 1 and 2 are attractive drug targets for a range of neurologic disorders; however, a critical barrier to ROCK-based therapeutics is ambiguity over whether there are isoform-specific roles for ROCKs in neuronal structural plasticity. Here, we used a genetics approach to address this...

journal_title：Brain structure & function

authors： Greathouse KM,Boros BD,Deslauriers JF,Henderson BW,Curtis KA,Gentry EG,Herskowitz JH

更新日期：2018-12-01 00:00:00

abstract：:Very preterm infants (≤ 31 weeks gestational age) are at high risk for brain injury and delayed development. Applying functional connectivity and graph theory methods to resting state MRI data (fcMRI), we tested the hypothesis that preterm infants would demonstrate alterations in connectivity measures both globally an...

journal_title：Brain structure & function

authors： Gozdas E,Parikh NA,Merhar SL,Tkach JA,He L,Holland SK

更新日期：2018-11-01 00:00:00

abstract：:Brain connectivity in non-human primates (NHPs) has been mainly investigated using tracer techniques and functional connectivity studies. Data on structural connections are scarce and come from diffusion tensor imaging (DTI), since gross anatomical white matter dissection studies in the NHP are lacking. The current st...

journal_title：Brain structure & function

authors： Decramer T,Swinnen S,van Loon J,Janssen P,Theys T

更新日期：2018-11-01 00:00:00

abstract：:The dorsal part of the developing telencephalon is one of the brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by the appearance of a new neurogenic niche in the embryonic subventricular zone (SVZ). Here, a new...

journal_title：Brain structure & function

authors： Docampo-Seara A,Lagadec R,Mazan S,Rodríguez MA,Quintana-Urzainqui I,Candal E

更新日期：2018-11-01 00:00:00

abstract：:The primary systems framework has been used to relate behavioural performance across many different language activities to the status of core underpinning domain-general cognitive systems. This study provided the first quantitative investigation of this account at both behavioural and neural levels in a group of patie...

journal_title：Brain structure & function

authors： Woollams AM,Halai A,Lambon Ralph MA

更新日期：2018-11-01 00:00:00

abstract：:Early-life stress (ELS) exposure has long-term consequences for both brain structure and function and impacts cognitive and emotional behavior. The basolateral amygdala (BLA) plays an important role in anxiety and fear conditioning through its extensive anatomical and functional connections, in particular to the media...

journal_title：Brain structure & function

authors： Guadagno A,Kang MS,Devenyi GA,Mathieu AP,Rosa-Neto P,Chakravarty M,Walker CD

更新日期：2018-11-01 00:00:00

abstract：:Ghrelin is a stomach-derived hormone that regulates a variety of biological functions such as food intake, gastrointestinal function and blood glucose metabolism, among others. Ghrelin acts via the growth hormone secretagogue receptor (GHSR), a G-protein-coupled receptor located in key brain areas that mediate specifi...

journal_title：Brain structure & function

authors： Cornejo MP,De Francesco PN,García Romero G,Portiansky EL,Zigman JM,Reynaldo M,Perello M

更新日期：2018-09-01 00:00:00

abstract：:Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remode...

journal_title：Brain structure & function

authors： Kong V,Devenyi GA,Gallino D,Ayranci G,Germann J,Rollins C,Chakravarty MM

更新日期：2018-09-01 00:00:00

abstract：:We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who und...

journal_title：Brain structure & function

authors： Planche V,Munsch F,Pereira B,de Schlichting E,Vidal T,Coste J,Morand D,de Chazeron I,Derost P,Debilly B,Llorca PM,Lemaire JJ,Marques A,Durif F

更新日期：2018-09-01 00:00:00

abstract：:The frontal cortico-basal ganglia network plays a central role in action selection, associative learning, and motivation, processes requiring the integration of information from functionally distinct cortical regions. The cortico-striatal projection is a likely substrate of information integration, as terminal fields ...

journal_title：Brain structure & function

authors： Heilbronner SR,Meyer MAA,Choi EY,Haber SN

更新日期：2018-07-01 00:00:00

abstract：:Dopaminergic neuromodulation is critically important for brain and cognitive integrity. The DRD2/ANKK1 Taq1A polymorphism is associated with striatal dopamine (DA) D2 receptor availability. Some previous studies have found that the A allele of the Taq1A polymorphism influences brain structure, but the results are inco...

journal_title：Brain structure & function

authors： Li X,Papenberg G,Kalpouzos G,Bäckman L,Persson J

更新日期：2018-07-01 00:00:00

abstract：:To provide information on the glutamatergic synapses on the trigeminal motoneurons, which may be important for understanding the mechanism of control of jaw movements, we investigated the distribution of vesicular glutamate transporter (VGLUT)1-immunopositive (+) and VGLUT2 + axon terminals (boutons) on the rat jaw-cl...

journal_title：Brain structure & function

authors： Park SK,Ko SJ,Paik SK,Rah JC,Lee KJ,Bae YC

更新日期：2018-06-01 00:00:00

abstract：:Children born very preterm (VPT) at less than 32 weeks' gestational age (GA) are prone to disrupted white matter maturation and impaired cognitive development. The aims of the present study were to identify differences in white matter microstructure and connectivity of children born VPT compared to term-born children,...

journal_title：Brain structure & function

authors： Young JM,Vandewouw MM,Morgan BR,Smith ML,Sled JG,Taylor MJ

更新日期：2018-06-01 00:00:00

abstract：:A hierarchical and modular organization is a central hypothesis in the current primate model of auditory cortex (AC) but lacks validation in humans. Here we investigated whether fMRI connectivity at rest and during active tasks is informative of the functional organization of human AC. Identical pitch-varying sounds w...

journal_title：Brain structure & function

authors： Häkkinen S,Rinne T

更新日期：2018-06-01 00:00:00

abstract：:Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long tim...

journal_title：Brain structure & function

authors： Zhu W,Ge X,Gao P,Li M,Guan Y,Guan X

更新日期：2018-05-01 00:00:00

abstract：:In the superior parietal lobule (SPL), the anterior part (area PE) is known to process somatosensory information, while the caudalmost part (areas V6Av and V6) processes visual information. Here we studied the visual and somatosensory properties of the areas PEc and V6Ad located in between the somatosensory and visual...

journal_title：Brain structure & function

authors： Gamberini M,Dal Bò G,Breveglieri R,Briganti S,Passarelli L,Fattori P,Galletti C

更新日期：2018-05-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward cu...

journal_title：Brain structure & function

authors： Zobeiri M,Chaudhary R,Datunashvili M,Heuermann RJ,Lüttjohann A,Narayanan V,Balfanz S,Meuth P,Chetkovich DM,Pape HC,Baumann A,van Luijtelaar G,Budde T

更新日期：2018-04-01 00:00:00

abstract：:Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this cell group may be involved in the regulation of energy homeostasis. In...

journal_title：Brain structure & function

authors： Péterfi Z,Farkas E,Nagyunyomi-Sényi K,Kádár A,Ottó S,Horváth A,Füzesi T,Lechan RM,Fekete C

更新日期：2018-04-01 00:00:00

abstract：:A loss-of-function polymorphism in the α5 nicotinic acetylcholine receptor (nAChR) subunit gene has been linked to both drug abuse and schizophrenia. The α5 nAChR subunit is strategically positioned in the prefrontal cortex (PFC), where a loss-of-function in this subunit may contribute to cognitive disruptions in both...

journal_title：Brain structure & function

authors： Howe WM,Brooks JL,Tierney PL,Pang J,Rossi A,Young D,Dlugolenski K,Guillmette E,Roy M,Hales K,Kozak R

更新日期：2018-03-01 00:00:00

abstract：:The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Pu...

journal_title：Brain structure & function

authors： Dieni CV,Ferraresi A,Sullivan JA,Grassi S,Pettorossi VE,Panichi R

更新日期：2018-03-01 00:00:00

abstract：:Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we...

journal_title：Brain structure & function

authors： Squires KE,Gerber KJ,Pare JF,Branch MR,Smith Y,Hepler JR

更新日期：2018-01-01 00:00:00

abstract：:Recent advances in diffusion-weighted MRI (dMRI) and tractography have enabled identification of major long-range white matter tracts in the human brain. Yet, our understanding of shorter tracts, such as those within the parietal lobe, remains limited. Over a century ago, a tract connecting the superior and inferior p...

journal_title：Brain structure & function

authors： Uesaki M,Takemura H,Ashida H

更新日期：2018-01-01 00:00:00

abstract：:The acoustic radiation is a compact bundle of fibers conveying auditory information from the medial geniculate nucleus of the thalamus to the auditory cortex. Topographical knowledge of this bundle in primates is scarce and in vivo diffusion-based tractography reconstructions in humans remains challenging, especially ...

journal_title：Brain structure & function

authors： Maffei C,Jovicich J,De Benedictis A,Corsini F,Barbareschi M,Chioffi F,Sarubbo S

更新日期：2018-01-01 00:00:00

abstract：:A history of intermittent, limited sucrose intake (LSI) attenuates the hypothalamic-pituitary-adrenocortical (HPA) axis stress response, and neuronal activity in the basolateral amygdala (BLA) is necessary for this HPA-dampening. LSI increases the expression of plasticity-associated genes in the BLA; however, the natu...

journal_title：Brain structure & function

authors： Packard AEB,Di S,Egan AE,Fourman SM,Tasker JG,Ulrich-Lai YM

更新日期：2017-12-01 00:00:00

abstract：:Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem...

journal_title：Brain structure & function

authors： Ruehl RM,Hinkel C,Bauermann T,Eulenburg PZ

更新日期：2017-12-01 00:00:00

abstract：:The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is...

journal_title：Brain structure & function

authors： Olivares-Moreno R,Moreno-Lopez Y,Concha L,Martínez-Lorenzana G,Condés-Lara M,Cordero-Erausquin M,Rojas-Piloni G

更新日期：2017-12-01 00:00:00

abstract：:The beneficial effects of physical exercise on brain health are well documented, yet how exercise modulates cerebrovascular function is not well understood. This study used continuous arterial spin labeling magnetic resonance imaging with a hypercapnic challenge to examine changes in cerebral blood flow and vascular f...

journal_title：Brain structure & function

authors： Cahill LS,Bishop J,Gazdzinski LM,Dorr A,Stefanovic B,Sled JG

更新日期：2017-11-01 00:00:00

abstract：:Interest in the study of brain connectivity is growing, particularly in understanding the dynamics of the structural/functional connectivity relation. Structural and functional connectivity are most often analysed independently of each other. Track-weighted functional connectivity (TW-FC) was recently proposed as a me...

journal_title：Brain structure & function

authors： Calamante F,Smith RE,Liang X,Zalesky A,Connelly A

更新日期：2017-11-01 00:00:00

abstract：:The octopus arm contains a tridimensional array of muscles with a massive sensory-motor system. We herein provide the first evidence for the existence of serotonin (5-HT) in the octopus arm nervous system and investigated its distribution using immunohistochemistry. 5-HT-like immunoreactive (5-HT-lir) nerve cell bodie...

journal_title：Brain structure & function

authors： Bellier JP,Xie Y,Farouk SM,Sakaue Y,Tooyama I,Kimura H

更新日期：2017-09-01 00:00:00

abstract：:Melatonin, through its different receptors, has pleiotropic functions in mammalian brain. Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated and non-receptor-mediated actions. With recent advancement in neuroanatomical mapping, we may now understand better the localizations o...

journal_title：Brain structure & function

authors： Ng KY,Leong MK,Liang H,Paxinos G

更新日期：2017-09-01 00:00:00

abstract：:Understanding the human brain is the ultimate goal in neuroscience, but this is extremely challenging in part due to the fact that brain tissue obtained from autopsy is practically the only source of normal brain tissue and also since changes at different levels of biological organization (genetic, molecular, biochemi...

journal_title：Brain structure & function

authors： Gonzalez-Riano C,Tapia-González S,García A,Muñoz A,DeFelipe J,Barbas C

更新日期：2017-08-01 00:00:00

abstract：:The architecture of the neocortex classically consists of six layers, based on cytological criteria and on the layout of intra/interlaminar connections. Yet, the comparison of cortical cytoarchitectonic features across different species proves overwhelmingly difficult, due to the lack of a reliable model to analyze th...

journal_title：Brain structure & function

authors： Cozzi B,De Giorgio A,Peruffo A,Montelli S,Panin M,Bombardi C,Grandis A,Pirone A,Zambenedetti P,Corain L,Granato A

更新日期：2017-08-01 00:00:00

abstract：:The interthalamic adhesion (ITA) is an understudied neuroanatomical structure that forms a bridge of tissue connecting the thalamus of each hemisphere across the midline whose functional significance remains largely unknown. The likelihood of ITA absence has been reported in some studies to be increased in males, but ...

journal_title：Brain structure & function

authors： Damle NR,Ikuta T,John M,Peters BD,DeRosse P,Malhotra AK,Szeszko PR

更新日期：2017-07-01 00:00:00

abstract：:Despite being historically one of the first brain regions linked to memory loss, there remains controversy over the core features of diencephalic amnesia as well as the critical site for amnesia to occur. The mammillary bodies and thalamus appear to be the primary locus of pathology in the cases of diencephalic amnesi...

journal_title：Brain structure & function

authors： Nelson AJD,Vann SD

更新日期：2017-07-01 00:00:00

abstract：:World-wide methamphetamine (meth) use is increasing at a rapid rate; therefore, it has become increasingly important to understand the synaptic changes and neural mechanisms affected by drug exposure. In rodents, 6-h access to contingent meth results in an escalation of drug intake and impaired cognitive sequelae typi...

journal_title：Brain structure & function

authors： Mishra D,Pena-Bravo JI,Leong KC,Lavin A,Reichel CM

更新日期：2017-07-01 00:00:00

abstract：:Cerebellar volume declines with aging. Few studies have investigated age differences in regional cerebellar volume (RCV) and their association with motor and cognitive function. In 213 healthy older adults, we investigated the association of age with motor skills, cognition and RCV. Subsequently, we studied the associ...

journal_title：Brain structure & function

authors： Koppelmans V,Hoogendam YY,Hirsiger S,Mérillat S,Jäncke L,Seidler RD

更新日期：2017-05-01 00:00:00